Antibacterial resistance is an important challenge in the treatment of bacterial infections, particularly when pathogens are resistant to commonly used antibiotics. One approach in medicinal chemistry is to combine two antibacterial pharmacophores in a single molecule. Oxazolidinones and fluoroquinolones are two important antibacterial classes with different structural features and biological targets. Earlier studies have demonstrated that oxazolidinone–quinolone and oxazolidinone–fluoroquinolone hybrids can be prepared by suitable linker strategies and can show useful antibacterial activity. The present revised study therefore focuses on the design, synthesis and characterization of oxazolidinone– fluoroquinolone hybrid compounds. The structural design is based on established compounds such as cadazolid and on published oxazolidinone–quinolone hybrid studies. The proposed compounds will be characterized by FTIR, 1H NMR, 13C NMR, mass spectrometry and, where available, chromatographic purity analysis. Antibacterial activity may be evaluated by a standardized broth microdilution method against selected bacterial strains. The study is intended to establish a chemically correct relationship between molecular structure and antibacterial activity and to identify promising structures for further investigation.
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